Bronchial Thermoplasty (BT) delivered by the Alair™ System is clinically proven to be a safe and effective treatment for severe asthma, with long-lasting benefits
Asthma Intervention Research 2 (AIR2) Trial: In this trial, one of the largest sham-controlled medical device trials in pulmonary medicine, patients with severe asthma showed significant improvement compared to sham-controlled patients 1 year after treatment with BT.1
Fewer exacerbations32%decrease in severe asthma exacerbations (requiring systemic corticosteroids)1
Fewer ER visits84%reduction in emergency room visits for respiratory related symptoms1
Fewer absences66%Fewer asthma-related days lost from work, school, and other activities1
Quality of life improvement79%of patients who were treated with BT reported a significant improvement in their asthma-related quality of life1
Asthma experts around the world talk about the effectiveness of BT
Proven to last at least 5 Years
Reduction in percentage of patients experiencing exacerbations seen at 1 year maintained for at least 5 years (primary endpoint).2
Additionally, there was a 44% decrease (average over 5 years) in the percentage of BT-treated patients having severe exacerbations, compared with 12 months prior to BT treatment.2
Reduction in ER visits seen at 1 year maintained for at least 5 years.2
Additionally, there was a 78% decrease (average over 5 years) in the percentage of BT-treated patients experiencing ER visits for respiratory symptoms, compared with 12 months prior to BT treatment.2
Asthma experts around the world say BT is Safe
No increase was seen in hospitalizations, asthma symptoms, or respiratory adverse events over the course of 5 years in patients treated with Bronchial Thermoplasty delivered by the Alair System.2
No structural changes in the airways that were clinically significant were due to BT at 5 years.2
Absence of clinically significant deterioration in lung function (pre-bronchodilator FEV1) at 5 years.2
Understand the risks of the Bronchial Thermoplasty procedure
As with any procedure, there are risks, and individual results may vary. The most common side effect of BT is temporary worsening of respiratory-related symptoms. This side effect typically occurs within a day of the procedure and resolves within 7 days on average with standard care. There is a small (3.4% per procedure) risk of these symptoms requiring hospitalization.1
Robust clinical research for a non-drug therapy in severe asthma clearly demonstrates the long-lasting benefit of BT
Bronchial Thermoplasty is supported by 4 clinical studies in asthma patients all with 5 year follow up: 3 of the trials were randomized, controlled, clinical trials.
- Castro M, et al, for the AIR2 Trial Study Group. Am J Respir Crit Care Med. 2010;181:116-124.
- Wechsler M et al. J Allergy Clin Immunol. 2013 Dec;132(6):1295-302.
- Castro M, et al, for the AIR2 Trial Study Group. Ann Allergy Asthma Immunol. 2011;107:65-70.
- Pavord I, et al, and the RISA Trial Study Group. Am J Respir Care Med. 2007;176:1185-1191.
- Cox G, et al. N Engl J Med. 2007;356:1327-1337.
- Thomson N, et al, for the AIR Trial Study Group. BMC Pulm Med. 2011;1-9.
- Cox G, et al. Am J Respir Crit Care Med. 2006;173:965-969.
- ‡ Asthma Intervention Research
- § Research in Severe Asthma